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HOCl effect on Rhinovirus – HRV

The effect of a low concentration of hypochlorous acid (HOCl) on rhinovirus infection of nasal epithelial cells.
Low concentrations of hypochlorous acid (HOCl) have been shown to exhibit both antibacterial and anti-influenza virus activity, but HOCl still has not been used to kill human rhinovirus (HRV). To model the antiviral effect of nasal irrigation with low-level HOCl in patients with the common cold, we tested the effects of a low concentration of HOCl on HRV infection of primary human nasal epithelial cells (HNEC).

Rhinovirus symptoms effected by HOCl


Cells were infected with HRV for 24 hours and treated with HOCl three times, for 5 minutes each time, at 12 hour intervals.

The effects of HOCl on rhinovirus-induced secretion of IL-6 and IL-8 were assessed by ELISA and HRV replication was determined by viral titration.
HOCl treatment significantly inhibited HRV-induced secretion of IL-6 and IL-8 and significantly reduced viral titer.

The effects of HOCl peaked at 1 minute after HOCl generation and decreased thereafter.

These in vitro findings indicate that nasal irrigation with low-level HOCl solution may improve clinical symptoms in patients with the common cold.

This study conducted by:
Yu, Myeong Sang & Park, Hyung Wook & Ja Kwon, Hyun & Ju Jang, Yong. (2011).  American journal of rhinology & allergy. 25. 40-4. 10.2500/ajra.2011.25.3545.

Related articles:
Distinct Types of Rhinovirus (HRV)

RESEARCHGATE publication #51450883