Tulsa Firefighters using Hypochlorous Acid

Tulsa firefighters have developed a fast way to clean their equipment using hypochlorous acid to disinfect and sanitize their equipment.  Hypochlorous Acid (HOCl) is 80-times more effective than chlorine bleach.

pure&clean™ has demonstrated effectiveness against viruses similar to COVID-19 on hard, nonporous surfaces. Therefore, pure&clean™ can be used against COVID-19 when used in accordance with the directions for use against Norovirus and Rhinovirus type 16 on hard, non-porous surfaces.

As a distributor of EPA Reg. No. 92108-1, the product pure&clean™ (EPA Reg. No. 92108-1-88098) is included on the list of products approved by the US EPA on the List-N.

HOCl Disinfectant

Personal hand hygiene and general surface cleanliness are paramount in the prevention and transmission of diseases. New viral and bacterial infections are on the rise, are increasingly deadly with increased morbidity and high mortality rates.  The global consequences are dire with the current coronavirus COVID-19 pandemic and  shortages of hand sanitizers, cleansers and disinfectants being reported. 

Most of these infections may be avoided through personal hand hygiene and surface cleanliness together with other preventative measures.   Personal hand hygiene and sanitized surfaces are the cornerstone principles of infection prevention. 

Per the Centre for Disease Control and Prevention (CDC), the following properties are considered ideal for a disinfectant:

  • Broad-spectrum efficacy - A good disinfectant should have the capability of targeting a wide variety of organisms, i.e. bacterial, viral, and fungi microorganisms. It should also have a high efficacy in its action as an antimicrobial.
  • Non-inflammable - This property enables disinfectants to be used over large areas with no health or safety concern including use in areas with flammable products such as kitchen and laboratories
  • Fast drying with short contact time – This property is essential to decrease the duration of bio-decontamination. A fast-acting agent quickly destroys microbes hence reducing the duration of potential contact with the microbes.
  • Non-toxic - The disinfectant should not harm the user and cause any discomfort. It should be user-friendly. 
  • Surface Compatibility - The disinfectant should have the capability to be used on most surfaces and instruments without corroding them or damaging their structural integrity.
  • Ease of use - An ideal disinfectant should be easy to use, store and discard, with clearly labeled instructions.
  • Odorless - Ideal disinfectants should be odorless or with a pleasant smell to facilitate regular use.
  • Alcohol Free - Alcohol based Hand Sanitizers are contributing to many types of bacteria becoming alcohol resistant.
  • Environmental friendly - An ideal disinfectant should have the capability of being used in the environment without causing any harm to the users and the environment.

In addition to the ideal properties, the product should also be cost-effective and easily accessible.  Hypochlorous acid (HOCl) fits into the CDC requirements for an ideal disinfectant as it has broad-spectrum efficacy, is odorless, non-flammable, non-toxic, fast drying, environmentally friendly and is easy to use.

Hypochlorous Acid - 500ppm HOCl (1 case - total 4 gallons)

pure&clean™ Disinfectant / Sanitizer (HOCl) is medical and food-grade quality making it ideal for hospitals, clinics, restaurants, schools, gyms, daycares, as well as personal and family use.  pure&clean™ product range is affordable, convenient, comes in a variety of packaging options and can be delivered to your door in just a few days.

The pure&clean™ Disinfectant / Sanitizer is batericidal, germicidal, virucidal, tuberculocidal, pseudomonacidal and staphlocidal exhibiting broad-spectrum antimicrobial properties. Pure&clean is alcohol free, non-flammable, easy to use and does not require rinsing after use.

A completely clean food contact surface prevents transmission of foodborne illnesses such as E-Coli and clostridium infections which cause food poisoning. Using pure&clean™ Disinfectant/Sanitizer on all food contact surfaces destroys such pathogens. The non-toxic and non-flammable nature of HOCl compounds gives pure&clean™ Disinfectant/Sanitizer an added advantage. It can be comfortably used on kitchen surfaces without fear of causing a fire, retaining toxic substances on the kitchen surfaces or polluting the air we breathe.

pure&clean™ Disinfectant/Sanitizer is a highly effective surface cleanser that can be used at home in the kitchen, nursery, restrooms, tables, work desks, in schools, restaurants, medical clinics, long-term care and hospitals. It is an HOCl multipurpose cleansing agent that deodorizes and cleans multiple surfaces, thus promoting hygiene and prevention of infection transmission. CDC advocates for proper and regular surface disinfection of regularly touched surfaces and objects such as doorknobs, light switches, kitchen cabinets, and countertops, to prevent the spread of microbes that cause infections. In the case of Coronavirus infections, it is recommended to use regular detergent and water to clean the surface followed by the use of a disinfectant such as pure&clean™ Disinfectant/Sanitizer.

 In conclusion, based on the CDC disinfection guidelines and Disinfection and Sterilization in Healthcare Facilities, it is safe to say that pure&cleanTM  Disinfectant / Sanitizer is a great choice to help protect your home and business environment.  It is recommended to frequently cleanse work and home surfaces such as bathrooms, high traffic areas, countertops, doors, light switches, office equipment, food preparation equipment and all contact surfaces. Visit the website at www.pureandclean.us.

HOCL Antimicrobial Action

Antimicrobial Action

Recent process control technology advancements in the manufacturing of  hypochlorous acid (HOCl) solutions based on electrochemistry have emerged as safe and viable wound cleaning agents as well as complementary therapies for the treatment of infections. Antimicrobial Action is a process of killing dieses.

Antimicrobial Action (HOCl) is a strong oxidant and tends to remove electrons from another substance. Its sodium salt, sodium hydroxide (NaClO), or its calcium salt, calcium hydroxide (Ca (ClO) 2) are commonly used in  disinfectants and disease prevention.

Hypochlorous Acid

HOCl exists as a natural endogenous constituent in humans and animals and is an important part of the innate immune system. HOCl is produced by neutrophil granulocytes, the most abundant type of white blood cells in mammals. HOCl is involved in the last step of the Oxidative Route in the fight against infection and invasion of foreign substances.

When a cell detects the invasion of a foreign substance it undergoes phagocytosis, during which the neutrophil ingests and internalizes microorganisms or foreign particles. This phagocytic event results in the secretion of reactive oxygen species and hydrolytic enzymes.

Oxygen consumption during the generation of reactive oxygen species, called “reactive explosion”, involves the activation of the enzyme NADPH oxidase, which produces large amounts of superoxide.

This highly reactive oxygen species is decomposed into hydrogen peroxide , Which is then converted to HOCl. HOCl exerts bactericidal properties and immediately destroys the bacteria swallowed by neutrophils. Despite the substantial activity of HOCl against microorganisms, it is not cytotoxic to human or animal cells.

HOCl effect on Rhinovirus – HRV

The effect of a low concentration of hypochlorous acid (HOCl) on rhinovirus infection of nasal epithelial cells.Low concentrations of hypochlorous acid (HOCl) have been shown to exhibit both antibacterial and anti-influenza virus activity, but HOCl still has not been used to kill human rhinovirus (HRV). To model the antiviral effect of nasal irrigation with low-level HOCl in patients with the common cold, we tested the effects of a low concentration of HOCl on HRV infection of primary human nasal epithelial cells (HNEC).

Rhinovirus symptoms effected by HOCl

Cells were infected with HRV for 24 hours and treated with HOCl three times, for 5 minutes each time, at 12 hour intervals.The effects of HOCl on rhinovirus-induced secretion of IL-6 and IL-8 were assessed by ELISA and HRV replication was determined by viral titration.HOCl treatment significantly inhibited HRV-induced secretion of IL-6 and IL-8 and significantly reduced viral titer.The effects of HOCl peaked at 1 minute after HOCl generation and decreased thereafter.These in vitro findings indicate that nasal irrigation with low-level HOCl solution may improve clinical symptoms in patients with the common cold.This study conducted by:Yu, Myeong Sang & Park, Hyung Wook & Ja Kwon, Hyun & Ju Jang, Yong. (2011).  American journal of rhinology & allergy. 25. 40-4. 10.2500/ajra.2011.25.3545.Related articles:Distinct Types of Rhinovirus (HRV)RESEARCHGATE publication #51450883

Healing Diabetic Wounds with HOCl

What is Diabetes ?

The body is made of millions of cells that need energy to function. The food you eat is turned into sugar, or glucose. It is one of many substances needed by the cells to make energy. Glucose is carried to the cells through the bloodstream, with the help of insulin. Insulin is a chemical hormone, which is manufactured by the pancreas. It acts as a glucose transporter and provides glucose to the target cells of your body.  Insulin levels in the blood vary with the amount of glucose present in the blood.

Diabetes is a chronic debilitating disease that makes it difficult for the cells of your body to get the glucose they need to make energy. As a result, the individual has high blood glucose (blood sugar), either because of inadequate production of insulin, or because of the unresponsiveness of the body's cells to insulin. Or in some cases, both. 

If you have diabetes, your blood sugar level is altered. This altered blood glucose level can cause different problems with other bodily functions such as eyes, kidneys, nerves and feet functionality. Long term complications may include heart diseases, sexual dysfunction and bone and joint disorders.

Diabetic Foot Wounds

Diabetic foot is one of the most dreadful complications of diabetes which can lead to prolonged hospitalization, restricted mobility, and sometimes limb amputation. The nerves become damaged due to poor blood circulation, resulting in delayed wound healing and high risk of infection. Burning pain, tingling sensations, weakness or loss of feeling are symptoms of diabetic foot. Because of sensation loss, temperature, pain and lack of attention to the feet become a danger. These become big risks from injury, unnoticed wounds and even ulcers. If left unnoticed, these wounds or ulcers can become infected, which is leads to serious conditions such as extended time in a care facility or limb amputations.

Diabetic patients with open wounds and infection should be treated aggressively due to the potential risks. The cornerstone of preventing these complications is to monitor the feet so that problems are spotted at the early stages. Other measures include keeping the feet clean and dry, ensuring the nails are well maintained and wearing socks and shoes that do not squeeze or rub the feet and fit comfortably.

Treatment of the diabetic wound comprises of five key factors which include wound assessment, tissue debridement, or removal of lifeless tissue from a wound, infection control, moisture balance and pressure reduction.

Diabetics are more prone to infections and therefore infections should be a top concern in any diabetic wound treatment plan. Different antibiotics and antiseptics are commonly used to reduce the growth of bacteria and their further spread. However, several recent studies have shown these methods might be causing more harm.

Topical antimicrobial or antiseptic agents like Povidone iodine and Hydrogen peroxide (H2O2) in chronic wounds remain in widespread use today and are successful in microbial eradication. However, they are found to be toxic to the cells involved in the wound healing process and their effectiveness varies between the types of microorganisms. Finding a non-cytotoxic, safe and effective wound cleanser was the biggest challenge for the physicians and healthcare staff. Hypochlorous acid was the solution.

Diabetic Wound Treatment with HOCL

Hypochlorous acid (HOCl) solution is one of the antiseptic agents used for the treatment of open diabetic wounds. It is a weak mixture of chemicals extensively used in deodorants and household bleach. It is naturally present in small molecules organically produced by white blood cells as a response to kill microorganisms before they invade the immune system. In recent years, clinical evidence shows HOCl to be safe with no negative effects on the cells of the body which take part in the wound healing process.

HOCl has a broad spectrum antimicrobial activity and is able to kill pathogens quickly. It is also effective in killing drug-resistant microorganisms. Studies have shown in addition to its antimicrobial activity, HOCl has the ability to remove strong odors from the wounds and reduces the discomfort of the wound by providing a cooling sensation.

Wound areas usually have a poor blood circulation, resulting in decreased oxygen supply, ultimately interfering with the healing process. HOCl increases the oxygenation of wound sites and supports the healing process. Another feature of HOCl is its significant anti-inflammatory activity in which it inhibits the degranulation of mast cells. This results in the reduction of pain and itching. Recent case studies have also shown the efficacy of HOCl in treating and managing the hypertrophic and keloid scars.

Ordinary HOCl anti-infective sprays contain a very small acid content and are suggested mainly to apply to a dressing. After wiping with HOCl and topping with a gentle rub of gauze, the healing time is improved with the wound losing unpleasant odors and becoming pain-free. Recommendations include the intralesional use of HOCl or other techniques that make sure the wound is covered with the solution for 15 minutes after debridement.

HOCl can also be used in the sterilization and debridement of the dead tissue of wounds observed at the source of injury.

Although the process of HOCl stabilization is very difficult, it is only a stabilized form of the acid that can help in cleansing wounds. A consultation with the physician is always necessary to see if it is a good idea to start using HOCl as a component of wound treatment.    

In short, HOCl is a unique and powerful antimicrobial cleanser against a variety of pathogens. It is safe, painless, low cost and rapidly improves the wound healing, especially open wounds of a diabetic foot. HOCl also significantly reduces the use of systemic antibiotics and has an important role in keeping dermal matrices and skin grafts hydrated. Studies on the matter have recommended the use of HOCl as a reliable diabetic wound cleanser. More controlled clinical studies are required to evaluate the efficacy and safety of HOCl and the outcomes of various methods of its application.

"Hypochlorous Acid for Wound Care." Advanced Tissue. June 25, 2014. Accessed February 07, 2018. https://www.advancedtissue.com/hypochlorous-acid-wound-care/.

 Biesman B, Cohen J, Gold M. Integrating HOCl into Wound Care: A New Paradigm for Patient Management. Practical dermatology. PDF file.  July, 2017. www.practicaldermatology.com/pdfs/0717_insert.pdf.

Wound Healing with Hypochlorous Acid

Stabilized HOCl solution had dose-dependent favorable effects on fibroblast and keratinocyte migration compared to povidone iodine and media alone. This performance demonstrates a stabilized HOCl solution as an ideal wound care agent.  Reference: PubMed PMID 31904191

HOCl Wound Care

Stabilized HOCl solution as an ideal wound care solution with a powerful and rapid killing effect on different types of microorganisms, antibiofilms, and microbicidal effect within the biofilm. Foremost, it has dose-dependent favorable effects on fibroblast and keratinocyte migration. These features lead to a stabilized HOCl solution as an ideal wound care agent. 

Wounds Research Issue: Volume 26 - Issue 12 - December 2014

HOCl Disinfectant of Surgical Implants

Disinfectant of Surgical Implants

HOCl antiseptic may be effective for cleaning biofilm-contaminated implant surfaces based on PubMed Abstract PMC4964533. HOCL Disinfectant of Surgical Implants.

Hypochlorous Acid is often used in the prevention of surgical site infections for procedures that install hardware or implants such as:

  • Knee Replacement Hardware
  • Hip Replacement Hardware
  • Breast Implants / Breast Implant Replacement
  • Clavicle Plate and Screws
  • Broken Fibula Plates and Screws
  • Proximal humerus fracture hardware
  • Distal Fracture hardware
  • Proximal Radius hardware

Recent study on the use of Hypochlorous Acid on Surgical Implants by the International Journal of Molecular Science